• Riris Wahyu Anggraini D-IV Nursing of Malang
  • Lenni Saragih Poltekkes Kemenkes Malang
  • Ni Luh Putu Eka Poltekkes Kemenkes Malang


The acute phase of the burns case is a form of critical trauma with a number of high mortality, Therefore, burn wounds is facing the complexity of problems that need particular attention. Aloe vera contains saponins active substances which are antiseptic and glucomannan as fibroblast growth that can help the healing process. The aim of this research is to examine the Aloe vera extracts toward the healing of burns grade two. The extract is made by maceration using solvent ethanol 70%. This research uses white male wistar rats (Rattus norvergicus)  who were divided into 4 groups that are given extra aloe vera gel concentration 10% aloe vera concentration 20% and the control group Silversulfadiazine1% and NaCl 0.9%. The observed parameters macroscopic picture (color, extent and presence or absence of exudate).All data is processed and analized statistically using SPSS 23. The results of the statistical analysis Paired Samples T-Test  and Independent Samples T-test showed that the average wound area  between NaCl 0,9%, Silver Sulfadiazine 1%, Aloe vera 10%, and Aloe vera 20% has no significant difference (p>0,05). Conclusion of this study is Aloe vera 10% and 20% have the same effect with Silver Sulfadiazine 1% for healing of skin  burns and applied to humans as an alternative treatment of early burns with a relatively cheap price.


Anderson, J. M. 2000. The Cellular Cascades of Wound Healing. In J. E. Davies (Ed), Bone Engineering. Toronto: Em Squared Inc, pp 81-93.
Badan Penelitian dan Pengembangan Kesehatan Kementrian Kesehatan RI. 2013. Riset Kesehatan Dasar (Riskesdas) 2013. Jakarta. ( diakses 20 september 2017.
Boudreau MD, Beland FA. An evaluation of the biological and toxicological properties of aloe barbadensis (miller), aloe vera. Journal of Environmental Science and Health. 2006; 24(1):103–54.
Ghodekar, SV, Chaudhari, SP, & Ratnaparakhi, MP 2012, „Development andcharacterizationsof silversulfadiazine emulgel for topical drug delivery‟,International Journal of Pharmacy and Pharmateutical Science, vol. 4, h.305. [online]. (diunduh 5 november 2016). Tersedia dari:
Gurtner, G.C. 2007. Wound Healing Normal and Abnormal. Grabb and Smith’s Plastic Surgery 6th Edition. Philadelphia: Lippincott Williams and Wilkins.
Jatnika, A. dan Saptoningsih, 2009. Meraup Laba dan Lidah Buaya, Agro Media Pustaka, Jakarta.
Jatnika, A., dan Saptoningsih. 2009. 1001 Obat Herbal. Jakarta: Agro Media Pustaka.
Johnson M. 2012. Laboratory Mice and Rats.Mater Methods 2:113. Diakses 21 Oktober 2017.
Lelley & Aucker,1999,Pharmakology and The Nursing Process Jakarta : ISBN
Lima, C.C., Pereira APC., Silva JRF., Oliveira LS., Resck MCC., Grechi CO., Bernardes MTCP., Olimpio FMP., Santos AMM., Incerpi EK., Garcia JAD. 2009. Ascorbic Acid for The Healing of Skin Wounds in Rats. Braz J Bio, 169(4), pp 1195-1201.
Moenadjat, Y. 2009. Luka Bakar Masalah dan Tata Laksana, edisi 4. Jakarta: Balai Penerbit FKUI. 90-105.
Regan, M. C and Barbul A, 1995. The Cellular Biology of Wound Healing. In
Regdl H, Schlag G, (Eds). Wound Healing. Berlin: Springer-Verlag, pp 2-13.
Robbins.Stanley L, Kumar V, Ramzi S.Buku Ajar Patologi.Ed 7.Jakarta : EGC,2007;80-83
Schwarts SI, Shires GT, Spencer FC, Daly JM, Fischer JE, Galloway C Principle of Surgery. 7th Edition. USA: Mc Graw-Hill Health Proffessions Divisions. 2005.
Sjamsuhidajat & De jong. 2012. Buku Ajar Ilmu Bedah. Ed. 3. Jakarta : EGC,2010;103-107
Tiwari, VK. 2012. Burn Wound: How It Differs From Other Wounds. Indian Journal of Plastic Surgery Vol. 45, 364-373.
World Wire Statistic Center. (2008). Informasi Bulletin Of The World Statistic Center. The Geneva Association. October 2008. Geneva.
How to Cite
ANGGRAINI, Riris Wahyu; SARAGIH, Lenni; EKA, Ni Luh Putu. TOPICAL EFFECTS OF ALOE VERA VEGETABLES EXTRACT OF 10%, AND 20% CONCENTRATION TOWARD THE CROSSOSCOPIC PICTURE OF FUEL GRADE II IN RATTUS NORVERCICUS RATS WISTAR SHEET. Jurnal Keperawatan Terapan (e-Journal), [S.l.], v. 5, n. 1, p. 53 - 64, mar. 2019. ISSN 2442-6873. Available at: <>. Date accessed: 24 aug. 2019. doi:
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