Factors Causing Primary Infertility In Couples Of Reproductive Age: Literature Review

  • Eko Sari Wahyuni Poltekkes Kemenkes Malang
  • Anggun Setyarini Poltekkes Kemenkes Malang

Abstract

Primary infertility, the inability of couples of reproduvtive age to conceive after 12 months of unprotected sexual intercourse, is a complex health problem with multiple causative factors. This literature review aims to identify and analyze factors associated with primary infertility in couples of reproductive age. The search method was conducted on electronic databases such as PubMed, ScienceDirect, and Google Scholar with the keywords “primary infertility”, “infertility factors”, “reproductive age couples”, and “literature review”. The results of the literature review found that primary infertility can be caused by various factors, both from the man (sperm quality disorders, sexual function, reproductive tract infections, chromosomal abnormalities, varicocele, lifestyle), woman (ovulation disorders, fallopian tubes, endometriosis, uterus, hormonal, lifestyle), and partner (age, lifestyle, environment, stress). These factors can be interrelated and result in primary infertility. It can be concluded that primary infertility is a complex and multifactorial health issue. Understanding these factors is important to help couples achieve pregnancy and improve their quality of life.

References

1. Sharma A, Mahajan C, Saraswathy K, Puri M, Babu N. Struggling with primary infertility: psychological well-being and associated factors in north Indian women. J Anthropol Surv India. 2022;71(1):68–83.
2. WHO. World Health Organization (WHO). Infertility: a clinical update. 2020; Available from: https://www.who.int/news-room/fact-sheets/detail/infertility
3. Dhandapani K, Kodavanji B, Nithyananda Madom Anantharaya V, Arun Kumar N. Prevalence and distribution of causes of infertility according to women’s age–a cross-sectional study in a tertiary healthcare hospital setup. J Basic Clin Physiol Pharmacol. 2023;34(1):27–32.
4. Lestari M, Refi WG, Dahliana MD, Oktavia T, Sari GN. Obesity is Associated with Primary Infertility in Women of Childbearing Age. J Midwifery. 2023;8(1):80–5.
5. ICMART, WHO, FIGO. International Committee for Monitoring Assisted Reproductive Technology (ICMART), World Health Organization (WHO), International Federation of Gynecology and Obstetrics (FIGO). International guidelines for the assessment, diagnosis and treatment of infertility. 2020; Available from: https://www.who.int/data/gho/indicator-metadata-registry/imr-details/national-policy-guideline-on-infertility-fertility-care
6. Hashmi AH, Asghar AR. Relationship between Depression and Social Support among Infertile Women. Pak Lang Humanit Rev. 2023;7(1):368–77.
7. Li S, Shen X, Qin XX, Fang S, Chen J, Yang HJ. Analysis of the factors influencing male infertility of reproductive age in Jinan. Eur Rev Med Pharmacol Sci. 2023;27(15).
8. Mulyani U, Sukarni D, Sari EP. Faktor-Faktor Yang Berhubungan Dengan Infertilitas Primer Pada Pasangan Usia Subur Di Wilayah Kerja Uptd Puskemas Lembak Kab. Muara Enim Tahun 2021. Nusant J Ilmu Pengetah Sos. 2021;8(8):2698–710.
9. Pasaribu IH, Rahayu MA, Marlina R. Faktor-Faktor Yang Mempengaruhi Infertilitas Pada Wanita Di Rumah Sakit Dewi Sri Karawang. HSG J. 2019;4(2):62–73.
10. Napitupulu E, Sembiring IS, Suherni T, Elnia E, Andriani R. Faktor–Faktor Yang Mempengaruhi Terjadinya Infertilitas Primer Pada Pasangan Usia Subur Di Puskesmas Pegajahan Kec. Pegajahan Kab. Serdang Bedagai Tahun 2023. J Vent. 2023;1(3):258–72.
11. Liang S, Chen Y, Wang Q, Chen H, Cui C, Xu X, et al. Prevalence and associated factors of infertility among 20–49 year old women in Henan Province, China. Reprod Health. 2021;18:1–13.
12. Legese N, Tura AK, Roba KT, Demeke H. The prevalence of infertility and factors associated with infertility in Ethiopia: Analysis of Ethiopian Demographic and Health Survey (EDHS). Plos One. 2023;18(10):e0291912.
13. Winarni S, Denny HM, Arifan F, Suwondo A, Kartini A, Susanto H. Risk Factors of Infertility Cases Among Shallot Farmers. Malays J Public Health Med. 2021;21(1):160–8.
14. Zhu C, Yan L, He C, Wang Y, Wu J, Chen L, et al. Incidence and risk factors of infertility among couples who desire a first and second child in Shanghai, China: a facility-based prospective cohort study. Reprod Health. 2022;19(1):155.
15. A’yun Q, Suhita BM, Laila SFN. Factor Analysis Infertility Events in Poly Gynekology Hospitals dr. H. Slamet Martodirdjo Pamekasan. J Res Public Health. 2020;1(2):93–110.
16. Alghamdi A, Bahnsawy N, Afefy N, Gouda ADK. Assessment of Prevalence and Risk Factors of Infertility among Saudi Women: A Cross Sectional Study. Indones J Glob Health Res. 2023;5(1):77–94.
17. Damayanti F, Hakim M, Anwar M, Puspandari DA. Characteristics Of People With Infertility In Indonesia Reflected In Fertiqol Scores. Malays J Public Health Med. 2022;22(1):100–8.
18. Penzias A, Bendikson K, Falcone T, Hansen K, Hill M, Jindal S, et al. Evidence-based treatments for couples with unexplained infertility: a guideline. Fertil Steril. 2020;113(2):305–22.
19. Szamatowicz M, Szamatowicz J. Proven and unproven methods for diagnosis and treatment of infertility. Adv Med Sci. 2020;65(1):93–6.
20. Obeagu EI, Njar VE, Obeagu GU. Infertility: Prevalence and consequences. Int J Curr Res Chem Pharm Sci. 2023;10(7):43–50.
21. Stern JE, Liu CL, Cui X, Cabral HJ, Farland LV, Coddington C, et al. Assisted reproductive technology treatment increases obstetric and neonatal risks over that of the underlying infertility diagnosis. Fertil Steril. 2022;117(6):1223–34.
Published
2024-06-28
How to Cite
WAHYUNI, Eko Sari; SETYARINI, Anggun. Factors Causing Primary Infertility In Couples Of Reproductive Age: Literature Review. Health Access Journal, [S.l.], v. 1, n. 2, p. 39-48, june 2024. ISSN 3047-4582. Available at: <https://ojs.poltekkes-malang.ac.id/index.php/HAJ/article/view/4520>. Date accessed: 23 july 2024. doi: https://doi.org/10.31290/haj.v1i2.4520.
Section
Table of Contents

Most read articles by the same author(s)

Obs.: This plugin requires at least one statistics/report plugin to be enabled. If your statistics plugins provide more than one metric then please also select a main metric on the admin's site settings page and/or on the journal manager's settings pages.