Effect of Cowpea Extract (Vigna Unguiculata) on the Proliferation of Epithelial Maturation (Epithelial Thickening) of Cervical Cells

bahasa indonesia

  • ita yuliani Poltekkes Kemenkes Malang
  • Jenny JS Sondakh Poltekkes Kemenkes Malang
  • Asworoningrum Yulindahwati Poltekkes Kemenkes Malang

Abstract

 Hypoestrogens in postmenopausal women cause many physical and psychological complaints, one of which is changes in the cervix, namely cervical atrophy/thinning (Baziat 2003: Gde et al., 2011). Hormone Replacement Therapy (HRT) estrogen therapy for a long time increases the risk of breast cancer and uterine cancer. It is necessary to find another alternative as a substitute for HRT, namely Cowpea (Vigna unguiculata) which is considered to be able to increase the proliferation of cervical maturation (epithelial thickening) epithelium. The design of this study is a true experimental design because there is a treatment, control group and randomization with the type of post test only control group. where testing was performed after the intervention. The intervention carried out was female Wistar strain rats that met the criteria for ovarectomy. There were 3 treatment groups: control rats (without treatment), rats were treated with cowpea extract 5 mg/KgBW and treated (P1) beta estradiol 5?g/kgBW (P2). This study wanted to determine the effect of cowpea extract (Vigna unguiculata) on the proliferation of cervical epithelial maturation (epithelial thickening) in hypoestrogen rats. The research place is the Pharmacology, Physiology and Anatomical Pathology Laboratory, Faculty of Medicine, Brawijaya University, Malang. Research Time The research was carried out for 4 months starting from August 2021 to November 2021. The results of the study using Oneway Anova obtained P Value (0.00) less than Alpha (0.05) so there are differences Treatment outcomes were significantly between groups (Control, P1 and P2). Tests of LSD and Mean Plots concluded that cowpea extract 5 mg/KgBW gave the most significant difference to the proliferation of maturation epithelium (epithelial thickening) of cervical cells (cervix).


 


 


 


Abstract


Ita Yuliani, Jenny JS Sondakh, Asworoningrum Y. 2021. Effect of Cowpea Extract (Vigna Unguiculata) on the Proliferation of Epithelial Maturation (Epithelial Thickening) of Cervical  Cells


 


Hypoestrogens in postmenopausal women cause many physical and psychological complaints, one of which is changes in the cervix, namely cervical atrophy/thinning (Baziat 2003: Gde et al., 2011). Hormone Replacement Therapy (HRT) estrogen therapy for a long time increases the risk of breast cancer and uterine cancer. It is necessary to find another alternative as a substitute for HRT, namely Cowpea (Vigna unguiculata) which is considered to be able to increase the proliferation of cervical maturation (epithelial thickening) epithelium. The design of this study is a true experimental design because there is a treatment, control group and randomization with the type of post test only control group. where testing was performed after the intervention. The intervention carried out was female Wistar strain rats that met the criteria for ovarectomy. There were 3 treatment groups: control rats (without treatment), rats were treated with cowpea extract 5 mg/KgBW and treated (P1) beta estradiol 5?g/kgBW (P2). This study wanted to determine the effect of cowpea extract (Vigna unguiculata) on the proliferation of cervical epithelial maturation (epithelial thickening) in hypoestrogen rats. The research place is the Pharmacology, Physiology and Anatomical Pathology Laboratory, Faculty of Medicine, Brawijaya University, Malang. Research Time The research was carried out for 4 months starting from August 2021 to November 2021. The results of the study using Oneway Anova obtained P Value (0.00) < Alpha (0.05) so there are differences Treatment outcomes were significantly between groups (Control, P1 and P2). Tests of LSD and Mean Plots concluded that cowpea extract 5 mg/KgBW gave the most significant difference to the proliferation of maturation epithelium (epithelial thickening) of cervical cells (cervix).


Key words : Cowpea extract, Cervical Epithelial Maturation Proliferation.

References

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Published
2022-04-28
How to Cite
YULIANI, ita; SONDAKH, Jenny JS; YULINDAHWATI, Asworoningrum. Effect of Cowpea Extract (Vigna Unguiculata) on the Proliferation of Epithelial Maturation (Epithelial Thickening) of Cervical Cells. Jurnal Pendidikan Kesehatan, [S.l.], v. 11, n. 1, p. 73-80, apr. 2022. ISSN 2442-7993. Available at: <https://ojs.poltekkes-malang.ac.id/index.php/jpk/article/view/3046>. Date accessed: 05 oct. 2022. doi: https://doi.org/10.31290/jpk.v11i1.3046.
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